% This is the sample input file for dsss1.exe. The explanations are given % in the lines started by "%". You may change the number(s) in the lines % without starting with "%". % % If you type 1 You have selected Slud and Wei method. % If you type 2 You have selected Lan and Demets method. % If you type 3 You have selected Haybittle method % If you type 4 None of the above and user will specify boundary. % This will take the program directly to the simulation stage. % Input a choice of the four methods: 1, 2, 3, 4 in the following line: 3 % % Type in output file name, put the name between " ": "exam1.log" % % Please input seed for random number generation: -123457 % % Input the number of interim analyses, up to nk=15 are allowed: 9 % Input time(s) of the k interim analyses, where k is the number you specified % in the previous line: 1 1.5 2 2.5 3 3.5 4 4.5 5 % % Input number of statistic(s), up to nih=5 are allowed: 1 % Input the ih rho(s) of the ih statistic(s) in Beta family, where ih is the % number you specified in the previous line: type 0 if you want logrank % statistic type 1 will give you Peto-Peto's statistics: 0 % Input the ih tau(s) of the ih statistic(s), type 0 will give you the % Harrington and Fleming family of statistics: 0 % % % Input the number of simulations in each iteration: 500 % % Input the type-I error: .05 % % Input 1 or 2 sided test, type 1 or 2: 2 % % The following input will only take effect if method 1 (Slud and Wei) % is selected. % Input the values of e(1),..., e(k): e(i) is the error spend on the i th, % interim analysis. The e's should sum up to the Type-I error. .003 .003 .003 .003 .003 .003 .003 .003 .003 .003 .003 .017 % % The following input will only take effect if method 3 (Haybittle) % are selected. % Input the b in the repeated significance test: b should be larger than 0 3 % % The following input will only take effect if method 4 (User specifies % boundary) is selected. % Input the k boundary values: The same set of boundary values will be used % for all the test statistics. If 2-sided test is specified, then the % negative of the values will be used as lower boundary. 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 % % The following input will only take effect if method 2 (Lan and DeMets) % is selected. % Input the choice of the use function: type 1, 2 or 3: % 1-------OBrien and Fleming type. % 2-------Pocock type. % 3-------Linear use function. % 1 % % Input the number of intervals to specify the baseline survival function: % Up to nl=20 are allowed. 1 % The left endpoint of the first interval is set to be zero. % Input the right endpoint(s) of the J interval(s), in increasing order % of magnitude, where J is the number in the last input. 5 % The survival function at 0 has been set to 1. % Input the J survival probabilities at the points specified in the last % input: The survival probabilities in between those points are % interpolated using the exponential distribution function. .5 % % Input accrual period and the lower and upper bounds on the accrual rate: % the product of these must be less than m set in the parameter line of the % source code dsss1.f. The initial m is set to be 7000 3 300 500 % % Input the desired power. The program will try to find the appropriate % accrual rate for the desired power. Please read the last few lines of the % output file to see if the desired power has been reached. Otherwise we % may either modify the bounds on the accrual rate (previous input) or the % desired power in the following line. .90 % % Input the alternative survival function. % Input the number of intervals (>=1) to specify the alternative survival % function: Up to 20 are allowed. 5 % Input the I right endpoint(s) of interval(s) for specifying alternative % survival function, where I is the number in the last input: 1 2 3 4 5 % If you want the alternative % survival function to be specified in the same way as the baseline % survival function, input 1. If you want the alternative survival % function to be specified by hazard ratio, input 2. Type 1 or 2: 1 % If you have typed 1 in the previous line, then you should input the I % survival probabilities, which should be non-increasing. If you have % typed 2 in the previous line, then you should input the I hazard % ratios, which should be nonnegative: .96 .88 .80 .70 .60 % % Input the censoring survival function for the baseline (control) group. % Input the number of intervals (>=1) to specify the survival function: % Up to 20 are allowed. 1 % Input the right endpoint(s) of interval(s) for specifying the % survival function: 5 % Input the survival probabilities at points specified in previous line: % the value should be between 1 and 0 and non-increasing. .933 % % Input the censoring survival distribution for alternative (treatment) group. % Input the number of intervals (>=1) to specify the survival function: % Up to 20 are allowed. 1 % Input the right endpoint(s) of interval(s) for specifying the % survival function: 5 % Input the survival probabilities at points specified in previous line: % the value should be between 1 and 0 and non-increasing. .937 % % Input the drop-in (out) rate. % Input the number of times to specify the drop-in rate(s): Up to 20 % are allowed:') 5 % Input the time point(s) for specifying drop-in rate(s): 0 1 2 3 4 % Input the drop-in rate(s): .03 .03 .03 .03 .03 % % Input the number of times to specify the drop-out rate(s): Up to 20 % are allowed: 5 % Input the time point(s) for specifying drop-out rate(s): 0 1 2 3 4 % Input the drop-out rate(s): .10 .10 .10 .10 .10 % % Input file ends here. This file should have exactly 154 lines including this line.